Supranuclear vertical gaze abnormalities in sporadic Creutzfeldt-Jakob disease.
نویسندگان
چکیده
Supranuclear gaze palsies are an uncommon feature of Creutzfeldt-Jakob disease (CJD). Most reported cases of CJD with features of supranuclear gaze palsy are familial. We report 2 patients with supranuclear vertical gaze abnormalities associated with spongiform changes in the midbrain. Both patients were found to have sporadic CJD after genetic testing. Distinguishing familial from sporadic CJD in this setting has important genetic and epidemiological implications.
منابع مشابه
Supranuclear Gaze Abnormality in Sporadic-Creutzfeldt Jacob Disease.
Sporadic Creutzfeldt-Jacob disease (sCJD) usually presents with typical clinical signs. Prodromal symptoms lasting for several weeks are followed by dementia, myoclonus, ataxia and abnormalities of vision (1). Supranuclear gaze palsies accompanying sCJD have rarely been reported. Some of these reported cases were initially diagnosed as progressive supranuclear palsy (PSP) and the diagnosis was ...
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عنوان ژورنال:
- Journal of the neurological sciences
دوره 253 1-2 شماره
صفحات -
تاریخ انتشار 2007